Austin's land and air transportation are favorable for materials distribution and business travel. Distribution takes advantage of the region's location in Central Texas at the intersection of I-35 and a network of U.S. and state highways.

Three of the nation's 10 largest cities – Houston, San Antonio and Dallas – are no more than three hours away. Laredo, major port of entry from Mexico is four hours away. State highway 130, is one of several recently completed roadway improvement projects speeding goods and traffic flow through Austin, connects to I-35 north of Georgetown and to I-10 east of San Antonio.

Austin-Bergstrom International Airport has nonstop service to 50 destinations in the U.S., Canada, Mexico and Europe, and served 15.8 million passengers in 2018. The airport is growing to meet the future needs of Austin with improvements ranging from terminal expansion to parking. Airlines operating out of Austin's airport include: Aeromexico, Air Canada, Alaska Airlines, Allegiant, American, British Airways, Delta, Frontier, JetBlue, Lufthansa, Norwegian, Southwest, Spirit Air, Sun Country, United, Vacation Express, and WestJet. Cargo shipped from ABIA in 2018 totaled 182.5 million pounds (and in past years the facility has handled as much as 357.3 million pounds). Austin's airport Austin-Bergstrom is entirely self-sustaining, generating its own revenue to cover its operating costs.